The experts behind the BioNTech coronavirus jab have developed another vaccine which they claim cures multiple sclerosis (MS) in mice.
The completely new MS vaccine works in a similar way to the coronavirus vaccine, manufactured in conjunction with US pharmaceutical giant Pfizer.
A piece of genetic material known as mRNA can be inserted into a person’s arm as well as forces the body’s own cells to produce a protein of which confers immunity.
inside the case of the coronavirus vaccine, of which protein mimics the virus’s protruding spike, kickstarting the immune system to start producing antibodies.
If a person later contracts the coronavirus, the immune system rapidly creates antibodies again as well as fights the infection before the item can take hold or spread.
inside the case of the MS vaccine, the mRNA technology stops the body’s own immune system coming from attacking neurons inside the brain as well as spinal cord which prevents the eventual loss of bodily function.
Clinical trials on mice revealed the jab cured the condition, stopped disease progression as well as restored some motor skills which had already been lost.
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Ugur Sahin (pictured with wife as well as fellow board member Ozlem Tuereci), CEO as well as founder of BioNTech has seen his personal fortune increase by some $4bn of which year
Clinical trials on mice revealed the MS jab cured the condition, stopped disease progression as well as restores some motor skills which had already been lost (stock)
The BioNtech coronavirus jab can be 95 per cent effective as well as was the first mRNA vaccine to ever receive approval for human use outside of clinical trials.
the item was approved by the MHRA on December 2, given to the first UK patient on December 8 as well as can be currently being administered to thousands every day.
Its approval has been hailed as a watershed moment in immunology as well as experts are hopeful the technology can eradicate more diseases.
mRNA can be genetic material which can be naturally found inside the human body.
the item can be used by human cells to carry messages as well as give instructions. DNA’s double-helix can be split in half, there can be a molecular substitution, as well as the item can be then sent out of the nucleus as well as into the cellular cytoplasm to relay the message.
Another part of the cell then reads its genetic sequence — the message — as well as goes about doing as the item can be told, which often means producing a specific protein.
After providing the blueprint, the mRNA molecule can be then destroyed by another part of the cell.
of which technology has been in development for decades yet has only currently reached a point where the item can be viable for use as a vaccine.
Pictured, Margaret Keenan, 0, became the first patient inside the United Kingdom to receive the Pfizer/BioNtech Covid-19 vaccine at University Hospital, Coventry, administered by nurse May Parsons, at the start of the largest ever immunisation programme inside the UK’s history
In a wonderful twist, the second person to get the Pfizer coronavirus jab inside the UK on December 8 was William Shakespeare coming from Warwickshire (pictured)
Inventor of Biontech jab adds $4bn to his fortune
The inventor of the BioNTech jab has added $4 billion to his personal fortune, while his investors have made double of which as countries continue to scramble to inoculate populations coming from coronavirus.
Ugur Sahin, CEO as well as founder of the German biotech firm of which has teamed up with Pfizer on its vaccine, has seen share prices soar over the past year.
With $5.24bn to his name, he can be currently the 478th richest person on the planet, according to the Bloomberg Billionaire’s Index.
High-profile BioNTech investors Thomas as well as Andreas Strungmann have profited even further over the last 12 months, both adding $8bn to their net worths to reach a total of more than $12bn.
Share prices have also risen in Pfizer as well as the makers of some other Covid vaccines, AstraZeneca as well as Moderna.
While their respective CEOs haven’t made the Billionaire’s Index, Brazil’s richest man, Jorge Paulo Lemann, can be financing AstraZeneca’s trials inside the country, as well as has seen his wealth rise $176m of which year.
Meanwhile, Moderna’s rise has seen the fortunes of professors Tim Springer coming from Harvard, as well as Robert Langer coming from MIT increase substantially as well, producing $2bn as well as $1.5bn in gains.
Share prices have soared in BioNTech over the last year after the item teamed up with Pfizer to develop a coronavirus vaccine
US-firm Moderna also made a mRNA vaccine for coronavirus, which last week received MHRA approval.
The Oxford-AstraZeneca jab does not use mRNA as well as instead uses a technique which has been around for decades, can be cheaper to produce, as well as easier to transport. the item received MHRA approval for emergency use inside the UK in December.
Dr Ugur Sahin, CEO of BioNTech, applied mRNA technology to multiple sclerosis.
The disease can be a result of the body’s own immune system attacking a protective layer of which surrounds neurons, called the myelin sheath, inside the brain as well as spinal cord.
The fatty substance allows for electric pulses to be passed through the cells as well as without the item messages coming from the brain fail to reach the muscles they are sent to.
As a result of of which interruption the patient progressively loses more function of their own body before the condition eventually stops them coming from being able to breathe.
Current treatments work by dampening the person’s immune system to delay as well as halt the degradation of the myelin sheath, yet of which leaves the person vulnerable to infections as they are unable to fight off any viruses or bacteria.
Dr Sahin’s theory was of which a vaccine could introduce genetic information which instructed the immune system of MS sufferers to not attack the proteins of which lead to myelin sheath deterioration.
The genetic material can be fragile as well as must be protected inside a durable case, made of lipids, during injection to ensure the item reaches cells before the item breaks down. The Covid-19 vaccine also has of which protective casing.
Dr Sahin’s team gave the vaccine as an injection to mice of which had autoimmune encephalomyelitis, an animal equivalent for human MS.
‘The vaccine blocked all clinical signs of MS in mice, while control animals experienced the typical symptoms of the disease,’ BioNTech said in a statement.
Some mice already had symptoms of MS before they received the vaccine, for example paralysis of the tail, as well as in these specimens the vaccine not only prevented further disease progression yet also reversed paralysis, restoring motor functions.
The full findings have been published inside the prestigious peer-reviewed journal Science.
Ugur Sahin as well as Ozlem Tuerci: The husband as well as wife ‘dream team’ behind the coronavirus vaccine
Physicians Ugur Sahin as well as Ozlem Tureci are the husband as well as wife ‘dream team’ behind the breakthrough Covid-19 vaccine of which will soon be rolled out across the UK.
The UK can be the first country inside the planet to approve the vaccine, which can be shown to be 95% effective as well as works in all age groups.
BioNTech chief executive Prof Sahin worked alongside his wife as well as the firm’s chief medical officer, Dr Tureci, to develop the jab.
BioNTech began preparing against the coronavirus in January after Prof Sahin read an article in a medical journal of which left him convinced the virus could spread into a full-blown pandemic.
BioNTech, founded just 12 years ago, has been working alongside 171-year-old titan of the pharmaceutical industry, Pfizer.
Prof Sahin came to Germany coming from Turkey when he was four years old. He graduated as a doctor coming from the University of Cologne in 1990.
Dr Tureci also of Turkish heritage, earned her MD at the Saarland University Faculty of Medicine in Homburg, Germany, as well as can be currently also the president of the Association for Cancer Immunotherapy.
Bonded by a shared love of medical research as well as oncology, the couple founded BioNTech in 2008, with the aim of pursuing a broader range of cancer immunotherapy tools.
On their wedding day in 2002, according to reports, the pair only briefly left their work at the lab to attend the registry office.
While the couple are said to be worth billions, Prof Sahin still reportedly cycles to work.
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Source : BioNTech creates a multiple sclerosis vaccine