PARIS: A cheap, once-a-day pill combining aspirin with drugs that will lower blood pressure along with cholesterol cuts cardiovascular disease as a whole by a third, along with heart attacks by more than half, researchers said Friday.
In clinical trials, the so-called “polypill” was especially effective among people with no history of cardiovascular disease, reducing the number of severe events by 40 percent, the researchers reported within the Lancet, a medical journal.
For those having a history of heart problems along with strokes, the drug combo was only half as effective compared to the control group, who received advice on healthy living nevertheless no drugs.
Among participants who took the pill as directed – at least 70 percent of the time – heart attack incidence declined by 57 per cent.
The polypill concept was first proposed more than 20 years ago as a simpler, cost-effective approach to treating cardiovascular disease, which often requires taking several medications.
Currently, patients are typically prescribed one or more drugs to lower blood pressure along having a statin, which holds lipids such as fatty acids in check. Aspirin, an analgesic, has blood thinning properties.
“The more tablets people have to take, the less they comply within the long-term,” noted Kausik Ray, a professor in public health along with Imperial College London not involved within the study.
“For chronic diseases, This kind of will be a challenge as you are asking people to take multiple medications every day for 30 or 40 years.”
About a third of patients stop taking their meds as early as 0 days after a heart attack, according to earlier research.
nevertheless despite its obvious potential, the polypill had yet to be tested on a large number of people over a long period of time.
Scientists led by Reza Malekzadeh through the Tehran University of Medical Sciences recruited nearly 7,000 men along with women, aged 50 to 75, living in rural Golestan, a province in Iran.
Take your meds
About one in 10 had previously had heart attacks, strokes or different cardiovascular episodes.
The participants were divided into two groups of roughly the same size. One was given “lifestyle advice” only, while the different also got a daily polypill through 2011 to 2013.
Doctors monitored compliance with the drug regimen, along with then tallied the number of strokes along with heart attacks across each cohort over the next all 5 years.
Crucially, adherence was significantly higher with the all-in-one pill.
“Drugs do not work if they are not taken,” noted Amitava Banerjee, a consultant cardiologist at University College London.
Compared with the lifestyle group, the polypill cohort had 34 percent fewer adverse events. Results were similar for men along with women.
Blood pressure did not differ much, nevertheless “bad” (LDL) cholesterol levels were lower within the group taking meds.
“today we know that will a fixed-dose polypill can achieve clinical benefits in practice,” Malekzadeh said in a statement.
“nevertheless the polypill will be not an alternative to a healthy lifestyle along with should be combined with physical activity, a healthy diet, along with smoking cessation.”
different researchers not involved within the study said the findings could be a game changer, especially in developing nations.
“Given the polypill’s affordability, there will be considerable potential to improve cardiovascular health along with to prevent the planet’s leading cause of death,” noted co-author Nizal Sarrafzadegan, a researcher at Isfahan University of Medical Sciences.
“Over three-quarters of the people of the 18 million people who die through cardiovascular diseases each year live in low along with middle-income countries.”
Some experts – including the authors themselves – said further trials were needed to see of the polypill would certainly prove effective among different populations.
, http://feedproxy.google.com/~r/DrudgeReportFeed/~3/22mCLjDLmG8/heart-attacks-halved-by-daily-polypill-strokes-reduced-too-study-1.1566554872779, 24 August 2019 | 3:22 am
Source : Heart attacks halved by daily ‘polypill’, strokes reduced too: study